Development, Wiring and Function of Cerebellar Circuits
Cerebellar development,
wiring and function
Our research
The goal of the lab is understanding how early alterations of the cerebellum are related to diverse neurodevelopmental disorders. The questions we pursue are grounded in determine, from a developmental perspective, how cerebellar abnormalities impact on the brain function.
We combine mouse genetics to develop animal models with cerebellar alterations, state-of-the-art histological, cellular, molecular biology methods and techniques, transcriptomics and functional analyses.
Our ultimate goal is to understand the contribution of the cerebellum to cognition in both typical development and developmental disorders and to translate this knowledge into clinical applications.
Our research is focused in two main research lines:
Cerebellar Long-range circuits
Understanding cerebellar long-range connectivity that relays cerebellar output to diverse brain areas.
We aim to elucidate how the cerebellum influences the development and function of remote brain circuits, with particular interest on the cerebellar modulation of the developing cortical circuits.
Cerebellar
microcircuits
Investigating the development and assembly of local cerebellar circuits. We seek to determine basic regulatory mechanisms underlying the formation and function of these circuit and how alterations in these processes derive in an abnormal function of the cerebellum.
The lab
We started at the Neuroscience Institute of Alicante in January of 2021.
The IN of Alicante is likely the top neuroscience institution in Spain.
It is a joint research center of the Consejo Superior de Investigaciones Científicas (CSIC) and the Universidad Miguel Hernández of Elche (UMH).
The institute assembles some of the world’s most renowned Neuroscientists in their fields and excellent research groups from neurodevelopmental and molecular neurobiology to systems.
As leading institution in Neuroscience, it provides an excellent environment for training new scientists.
Funding
Our research is currently supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (GA No. 950013), the Spanish Ministry of Science and Innovation through the Grant PID2021-122986NA-I00 funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe” and the Plan Gen-T from the Generalitat Valenciana (SEJIGENT/2021/036).
We also received funding from the Severo Ochoa Excelence Program and H2020 (MSCA-IF).
